Chloride and hydrogen ions are secreted separately from the cytoplasm of parietal cells and mixed in the canaliculi.
![Chloride and hydrogen ions are secreted separately from the cytoplasm of parietal cells and mixed in the canaliculi. Chloride and hydrogen ions are secreted separately from the cytoplasm of parietal cells and mixed in the canaliculi.](https://static.zoonar.de/img/www_repository7/33/cd/38/10_040445e88c434bef8064a97ab66b8d86.jpg)
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Pepsinogen reacts with hydrochloric acid (HCl) in the stomach and turns into pepsin. The purpose of this mechanism is to reduce the negative effect of this enzyme against the cell or channel in which it is secreted. 3D illustration
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